Clinical Evidence


Detection of Uncontrolled PD Symptoms

A large proportion of Parkinson’s Disease patients have uncontrolled symptomology

Uncontrolled Parkinson’s Disease (PD) is widespread.  It is estimated that up to 80% of Parkinson’s Disease patients have uncontrolled symptomology and these, typically treatable, symptoms can cause poor quality of life & significant patient morbidity.1-3

PKG detects 78% of patients have uncontrolled PD symptoms

A study published in Nature (njp) Parkinson’s Disease, 78% of patients were found to have had uncontrolled symptoms via the PKG.  Subsequent treatment of those patients towards control guided by PKG target ranges resulted in significant improvements in patient outcomes including quality of life and cognition (significant improvement in PDQ-39 of 8.5 [p = 0.03]; Total UPDRS improved by 8 [p <0.0009]; NMS Quest improved by 1 [p= 0.02]; and MOCA scores improved by 2 [p = 0.02]).2


Of the Time Influence Change in Medications

75% PD patients’ medications changed because of the PKG

A recently published study demonstrated that the PKG changed medications in PD patients 75% of the time. MDS-UPDRS III score improved 4.8 points from 28.9 to 24.1 points (p = 0.028); both statistically significant and clinically meaningful difference. MDS-UPDRS IV score improved from 4.1 to 3.0 points (p = 0.07).  The PKG influenced treatment plans demonstrated by improvement in Global Impression of Improvement Positive changes in both the clinician (17/28; 61%) and patient-reported (13/24; 54%). Clinical management plans enhanced by PKG led to different recommendations in 29.4% of cases compared with standard of care due to higher rates of bradykinesia, dyskinesia, tremor, and fluctuations identified by PKG. 4

47% of physicians changed the medical decision after using the PKG

A study completed in the UK demonstrated that the PKG changed the medical decision of the physician 47% (80 of 171 decisions) of the time.  34% (27 of 80 changed decisions) were decisions related to referring patients for advanced therapies (e.g. DBS, infusional drugs); 29.2% of 171 (49 patients) were considered for advanced therapies and in 26% (13 of 49) advanced therapy was no longer determined to be considered the next step.6


Show Improved Dialogue on PD Symptoms

59% reported improved dialogue with patients

Additional impact of the PKG on Patient Care reported by clinicians:

Improved education about illness (15%), symptoms (29%), ability to assess patient PD symptoms (33%); total of 77% across 65 visits5

Patient feedback from use of PKG in clinical care visits reported:

74% reported PKG to be somewhat or very valuable in helping take medications on time (by function of the medication reminders), explain symptoms and provide additional information to manage care for PD

61% found valuable in providing data to the physician on daily movement during daily activities

57% stated the PKG was valuable in overall management of symptoms

52% of patients found the PKG valuable in taking medications on time5


  1. Odin P, Chaudhuri KR, Volkmann J, Antonini A, Storch A, Dietrichs E, Pirtošek Z, Henriksen T, Horne M, Devos D, Bergquist F. Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson’s disease. NPJ Parkinsons Dis. 2018 May 10;4:14.
  2. Farzanehfar P, Woodrow H, Braybrook M, McGregor S, Evans A, Nicklason F, Horne M. Objective measurement in routine care of people with Parkinson’s disease improves outcomes. NPJ Parkinsons Dis. 2018 Apr 3;4:10.
  3. P. Lynch, R. Pahwa, F. Bergquist, M. Horne. Objective Data in Parkinson’s Disease: A description of over 20,000 Parkinson’s symptom scores across the world using the Personal KinetiGraph (PKG) [abstract]. Mov Disord. 2018; 33 (suppl 2). Accessed December 12, 2018
  1. Nahab FB, Abu-Hussain H, Moreno L. (2019) Evaluation of Clinical Utility of the Personal KinetiGraph in the Management of Parkinson’s Disease. Advances in Parkinson’s Disease, 8, 42-61.
  2. Joshi R, Bronstein JM, Alcazar J, Yang D, Joshi M, Hermanowicz N. An Observational Study of PKG Movement Recording System Use in Routine Clinical Care of Patients with Parkinson’s Disease. Movement Disorders Front. Neurol., 01 October 2019 |
  3. Carroll C, Kobylecki C, Silverdale M, Thomas C. Impact of Quantitative Assessment of Parkinson’s Disease-Associated Symptoms Using Wearable Technology on Treatment Decisions. Journal of Parkinson’s Disease. DOI: 10.3233/JPD-191623.