Empowering lives through precision medicine in neurology

We believe every person with a neurological condition deserves to live their best life every day.  We leverage the world’s largest body of clinical evidence in neurology, to create and deliver precision medicine by accelerating the research, approval, and adoption of treatments.

PKG-Image---20

Upgrading the standard of care and improving outcomes for people with neurological movement disorders.

The PKG® system provides a continuous, objective assessment of movement disorder symptoms, such as tremor, dyskinesia and bradykinesia during activities of daily living and in the patient’s home environment.  Our industry leading, clinically validated FDA Class II cleared algorithms power precision medicine for patients, clinicians and our life science partners.

100%

Improvement in MDS-UPDRS score using PKG vs. standard of Care

75%

Of the time PKG influences a
change in medications

59%

Improvement in Patient Dialogue and engagement reported by Clinicians

89%

Of patients said PKG provided data to physician they could not provide

93%

Of PD patients said PKG
was easy to use

12+

Studies validating reliability & responsiveness

Process

After receiving the PKG Watch, patient data is collected continuously during activities of daily living and sleeping in the home environment and can be programmed to remind the patient to take their prescription medications and then records their compliance.

The PKG Watch, with its 10 day battery life, is worn continuously throughout the
day and night recording activity and inactivity in millisecond clips.

The PKG® system consists of a wearable recording device, patented algorithms and an HCP portal which provides summaries and advanced analytics to help better understand patients progression and responsiveness to treatments.  Patient and caregiver apps are also available.

Wearable

Patient & caregiver
apps

Advanced algorithms for neurological disorders

HCP portal with advanced analytics

PKG Algorithms

The PKG® system contains the most comprehensive clinically validated algorithms available in the neurological movement disorder market.  PKG algorithms not only capture and process objective measurement of persons with movement disorders; PKG also provides prospective insights and guidance on treatment decisions and adjustments.

Bradykinesia

Dyskinesia

Tremor

Daytime Immobility

Fluctuations

Nighttime
sleep

Device Assisted Therapy (CTS)

Gait &
walking

Wearing
off

Symptom & Side Effect Mgmt (in R&D)

Rx
Titration (in R&D)

Rx
Compliance

Off Wrist Detection

Offerings

Clinical Care

Clinical Care

Supporting both in-clinic care and remote patient monitoring, PKG Health offers an FDA cleared, CE marked and TGA approved system to measure and inform treatment decisions for patients with neurological movement disorders combining:

Wearables

PKG Health collects patient data and provides alerts through both its own proprietary wearable (with a 7 day battery life) and a BYOD option, depending on requirements.

Patient and Caregiver Apps

Available on iOS and Android offering customized, white labelled patient education, side effect management, patient reported outcomes, titration guidance and more.

Algorithms

Proven and patented using Al/ML. These measurement and digital therapeutics algorithms inform treatment decisions and provide patients and HCPs insight into their condition, medications, etc..

HCP Portal

Provides one location for managing all patients. It contains longitudinal analytics on the patient condition evolution, enables staff to setup medication reminders and provides summary scores to guide care.

Clinical Trial Services (CTS)

Clinical Trial Services (CTS)

For life sciences sponsors and their CROs, clinical trials are all about capturing patient responses to novel treatments. PKG Health stands alone as the industry leader in capturing objective patient motor symptoms and key patient reported outcomes (PROs) using wearables and our white labelled apps. With over 4,300 motor and non-motor data points collected weekly on each patient, delivered intelligently via clinically validated and patented algorithms, clinical trials can be accelerated with objective endpoints to better quantify results.  Our technology and services have been deployed in over 70 clinical studies globally

Digital Therapeutics (DTx)

Digital Therapeutics (DTx)

For life sciences companies, data-driven brand decisions are of utmost criticality. Yet for many patients, this is overwhelmingly not the case. The most critical success factor is ensuring both you and your HCP customer thoroughly understand the facts on your shared patient; their behavior, their challenges, their response to therapy. PKG Health offers life science companies white labelled digital companions with embedded DTx to help brands maximize their market opportunity. Objective real-time patient intelligence via patented, clinically validated algorithms, patient education and engagement and powerful AI/ML analytics optimizes the patient journey.

History

2007

Global Kinetics Corporation Established

2014 - 2016

Regulatory Clearances & Initial Patents

2016

PKG Algorithms for Routine Clinical Care Expand globally

2017- 2018

Clinical Research Algorithms expanded

2019

Continuous Use Use Case Launched

2020 - 2021

Pivotal Data Published

2022

R&D for New Algorithms
US Market Initiation with VA

2023

Gen 3.0 Wearable
PKG4 Reporting
Middle East Expansion
R&D on Digital Biomarkers

Leadership

Zach
Henderson

Chief Executive
Officer

Thomas
Ulmer

Chief Financial & Operating Officer

Yuri
Maricich

Chief Medical &
Scientific Officer

Neil
Stevens

Vice President
Europe/Middle East

Muhammad
Umer

Vice President
Technology

Dan
Bennett

Vice President
Partnerships

Global Kinetics Corporation Founded by Professors Robert Griffiths and Malcolm Horne

Regulatory Clearances

  • FDA 510(k)
  • TGA (2015)
  • CE Mark (2016)

Standard Scores for Routine Clinical Care

  • Bradykinesia
  • Dyskinesia
  • Tremor
  • Fluctuations
  • Daytime Immobility

Research Scores (CTS)

  • Nighttime Sleep
  • Wearing OFF (2019)
  • Device Assisted Classifier (2019)
  • 30-Minute Interval (2020)
  • Active BKS
  • Adjusted DKS
  • Early Morning OFF

Continuous Use Model

  • Charging and cellular enabled data for continuous patient use
  • Early use in CTS

Pivotal Data Published

US Market Initiation

  • Signed VA contract
  • Integrated PKG into clinical workflow

R&D for new Algorithms

  • Advanced Gait Measures
  • Falls Prediction
  • Postural Stability

Generation 3 Watch

Launch in UAE

R&D on AI identifying digital biomarkers

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